Pseudomonas aeruginosa PAO-1 Lipopolysaccharide-Diphtheria Toxoid Conjugate Vaccine: Preparation, Characterization and Immunogenicity
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Pseudomonas aeruginosa PAO-1 Lipopolysaccharide-Diphtheria Toxoid Conjugate Vaccine: Preparation, Characterization and Immunogenicity
BACKGROUND Treatment of Pseudomonas aeruginosa PAO-1 infections through immunological means has been proved to be efficient and protective. OBJECTIVES The purpose of this study was to produce a conjugate vaccine composed of detoxified lipopolysaccharide (D-LPS) P. aeruginosa and diphtheria toxoid (DT). MATERIALS AND METHODS Firstly, LPS was purified and characterized from P. aeruginosa PAO1...
متن کاملpseudomonas aeruginosa pao-1 lipopolysaccharide-diphtheria toxoid conjugate vaccine: preparation, characterization and immunogenicity
conclusions vaccine based on the conjugation of p. aeruginosa pao-1 lps with dt increased anti-lps antibodies and had a significant potential to protect against pseudomonas infections. background treatment of pseudomonas aeruginosa pao-1 infections through immunological means has been proved to be efficient and protective. objectives the purpose of this study was to produce a conjugate vaccine ...
متن کاملImmunogenicity comparison of conjugate vaccines composed of alginate and lipopolysaccharide of Pseudomonas aeruginosa bound to diphtheria toxoid
BACKGROUND AND OBJECTIVES Treatment of Pseudomonas aeruginosa infections is greatly hampered by innate and acquired antibiotic resistance. The goal of this study was to compure the immunogenicity of conjugates of P. aeruginosa depolymerized alginate-diphtheria toxoid (D-ALGDT) and P. aeruginosa detoxified lipopolysaccharidediphtheria toxoid (D-LPSDT) in mouse model. MATERIALS AND METHODS Algi...
متن کاملimmunogenicity comparison of conjugate vaccines composed of alginate and lipopolysaccharide of pseudomonas aeruginosa bound to diphtheria toxoid.
background and objectives: treatment of pseudomonas aeruginosa infections is greatly hampered by innate and acquired antibiotic resistance. the goal of this study was to compure the immunogenicity of conjugates of p. aeruginosa depolymerized alginate-diphtheria toxoid (d-algdt) and p. aeruginosa detoxified lipopolysaccharidediphtheria toxoid (d-lpsdt) in mouse model. materials and methods: algi...
متن کاملsynthesis, characterization and immunological properties of escherichia coli 0157:h7 lipopolysaccharide- diphtheria toxoid conjugate vaccine
background and objective: escherichia coli o157:h7, an emerging pathogen, causes severe enteritis and the extraintestinal complication of hemolytic-uremic syndrome. the goal of this study was to evaluate the conjugate of e. coli o157: h7 lipopolysaccharide (lps) with diphtheria toxoid (dt) as a candidate vaccine in mice model. material and methods: lps from e. coli o157:h7 was extracted by hot ...
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ژورنال
عنوان ژورنال: Jundishapur Journal of Microbiology
سال: 2015
ISSN: 2008-3645,2008-4161
DOI: 10.5812/jjm.8(5)2015.17712